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Finasteride: rare reports of depression and suicidal thoughts . 3 Topical preparations for rosacea . Dose Changes: Medroxyprogesterone acetate: hot flushes caused by long-term androgen suppression in men with prostate cancer .

Fluoxetine: menopausal symptoms in women with breast cancer . Citrous Bioflavonoid Compound 100 mg Capsules. Ustekinumab for treating active psoriatic arthritis . The revised guidance on atrial fibrillation in BNF 56 is an essential read.

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Please forward this error screen to 173. Target cholesterol concentrations are given for the secondary prevention of cardiovascular events together with advice on adjusting drug treatment if these concentrations are not achieved. Lactic Acid bacillus 90 million spores Tablets.

An overview of some of the most significant changes is available here. For full details see Changes for this edition. Trametinib: risk of gastrointestinal perforation and colitis . Numerous changes are made for each new edition of the BNF. Vaccines: updates to Public Health England’s Green Book on use of live attenuated vaccines . BNF 56 highlights the risk of suicidal thoughts and behaviour with antiepileptic drugs and recommends that patients should seek medical advice if they develop mood changes or suicidal thoughts.

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Trametinib in combination with dabrafenib for treating unresectable or metastatic melanoma . Short bowel syndrome: new guidance on management. Human papillomavirus vaccine , Levothyroxine sodium, Teicoplanin. Coeliac disease: new guidance on management. Ticagrelor for preventing atherothrombotic events after myocardial infarction . Idelalisib: updated indications and advice on minimising the risk of infection .

Antibacterials, principles of therapy: new guidance on early management of sepsis. Ranolazine 500 mg extended release Tablets. Atezolizumab for untreated locally advanced or metastatic urothelial cancer when cisplatin unsuitable .

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Tamoxifen: chemoprevention of breast cancer . Ciprofloxacin 500 mg with Tinidazole 600 mg Tablets. The focus was on creating or enhancing independent drug information services in countries with limited resources and experienced personnel.

Denosumab: osteonecrosis of the jaw and hypocalcaemia . 2 Tablets of Amoxicillin 750 mg. Raloxifene hydrochloride: chemoprevention of breast cancer . Note, the old site will only be available until June this year, so it’s important you familiarise yourself with the changes. As part of an ongoing commitment to making BNF knowledge more accessible, a new online revision aid, BNF Prescribing Practice for Medical Students, will help students assess and diagnose common clinical conditions, and improve their knowledge of safe prescribing while using the latest BNF.

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Diabetes, pregnancy and breast-feeding: updated guidance on management. Obinutuzumab with bendamustine hydrochloride for treating follicular lymphoma refractory to rituximab . Daclizumab for treating relapsing-remitting multiple sclerosis .

Cetuximab and panitumumab for previously untreated metastatic colorectal cancer . Significant Changes: Risk of venous thromboembolism with combined hormonal contraceptives. Certolizumab pegol for treating active psoriatic arthritis after inadequate response to DMARDs . Sorafenib for treating advanced hepatocellular carcinoma . Parkinson’s disease: updated guidance on management.

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BNF 56 recommends that a statin remains the drug of choice for the primary and secondary prevention of cardiovascular events. Canagliflozin, dapagliflozin and empagliflozin as monotherapy for treating type 2 diabetes . Significant Changes: Benzodiazepine withdrawal advice updated, Metoclopramide: risk of neurological adverse effects—restricted indications, dose and duration of use , Ocriplasmin for treating vitreomacular traction . Emergency contraception: updated guidance on management. Vismodegib for treating basal cell carcinoma .

BNF now gives you faster, easier access to drug information, along with an improved format and clearer layout. Ramucirumab: for previously treated locally advanced or metastatic non-small-cell lung cancer . Please start using this and take advantage of the improvements. Nivolumab for previously treated advanced renal cell carcinoma . Collagenase clostridium histolyticum for treating Dupuytren’s contracture . Eribulin for treating locally advanced or metastatic breast cancer after 2 or more chemotherapy regimens .

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Pegylated liposomal irinotecan hydrochloride for treating pancreatic cancer after gemcitabine . Ustekinumab for moderately to severely active Crohn’s disease after previous treatment . Nivolumab for treating squamous cell carcinoma of the head and neck after platinum-based chemotherapy .

Information about changes made for this edition is available here. Significant Changes: Antiepileptic drugs: new advice on switching between different manufacturers’ products for a particular drug , Prevention of secondary case of Haemophilus influenzae type b disease, Mefloquine , Beta2 agonists for premature labour . Alendronic acid, ibandronic acid and risedronate sodium for treating osteoporosis . All accounts have been provided with access details for the new site.

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Cabazitaxel: for hormone-relapsed metastatic prostate cancer treated with docetaxel . Significant Changes: Concomitant use of drugs affecting the renin-angiotensin system , Ivabradine: risk of bradycardia , Canagliflozin in combination therapy for treating type 2 diabetes . Cetuximab for treating recurrent or metastatic squamous cell cancer of the head and neck . For further details on changes in the BNF click on changes. Significant Changes: Haloperidol , Domperidone: risk of cardiac side-effects—restricted indication, new contra-indications, reduced dose and duration of use , Treatment of epilepsy , Strontium ranelate , Meningococcal group C conjugate vaccine .

Significant Changes: Aceclofenac: updated cardiovascular advice—new contra-indications in certain established cardiovascular diseases , Diclofenac potassium, 12. HIV infection: new guidance on pre-exposure prophylaxis. Pembrolizumab for advanced melanoma not previously treated with ipilimumab . Exocrine pancreatic insufficiency: updated guidance on management. Urinary retention: updated guidance on management. Cladribine tablets for treating relapsing-remitting multiple sclerosis .

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BNF 56 provides valuable advice on which cephalosporins to use in patients with a history of serious penicillin allergy when other suitable antibacterials are not available. Significant Changes: Interchangeability of oral mesalazine preparations, Pixantrone monotherapy for treating multiply relapsed or refractory aggressive non-Hodgkin’s B-cell lymphoma , Aflibercept for treating visual impairment caused by macular oedema secondary to central retinal vein occlusion , Local anaesthetic-induced cardiovascular toxicity . Updated table on management of acute asthma and a new table on risks associated with HRT. Controlled drugs and drug dependence: updated guidance.

Aflibercept for treating choroidal neovascularisation . Sodium valproate: resources to support the safety of girls and women who are being treated with valproate . Alirocumab: for treating primary hypercholesterolaemia and mixed dyslipidaemia .

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2 Tablets of Clarithromycin 250 mg. Evolocumab for treating primary hypercholesterolaemia and mixed dyslipidaemia . Talimogene laherparepvec for treating unresectable metastatic melanoma . Naltrexone with bupropion for managing overweight and obesity . 12-9-2014: BNF September 2014 Update This update contains 6 significant changes, 1 dose change and 3 new preparations. Mepolizumab for treating severe refractory eosinophilic asthma .

Methoxy polyethylene glycol-epoetin beta: risk of severe cutaneous adverse reactions . Riociguat: not for use in pulmonary hypertension associated with idiopathic interstitial pneumonias . Ceritinib for previously treated anaplastic lymphoma kinase-positive non-small cell lung cancer .