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Rubinstein P, Carrier C, Scaradavou A, et al. HLA-C antigen mismatch is associated with worse outcome in unrelated donor peripheral blood stem cell transplantation.
A 24 Week, Multicenter, Randomized, Double-Blind, Parallel Group, Phase 3 Trial with a 28 Week Long Term Safety Extension Period Evaluating the Safety and Efficacy of Dapagliflozin 10 mg in T2DM Patients aged 10-24 years. In addition, bone marrow or PBSCs can be T-cell depleted by several methods, and the resultant stem cell product has very different properties.
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Cord-Blood Transplantation in Patients with Minimal Residual Disease. Pidala J, Lee SJ, Ahn KW, et al. Davila ML, Riviere I, Wang X, et al. Porter DL, Collins RH Jr, Shpilberg O, et al. Impact of allele-level HLA matching on outcomes after myeloablative single unit umbilical cord blood transplantation for hematologic malignancy.
Impact of pretransplant minimal residual disease after cord blood transplantation for childhood acute lymphoblastic leukemia in remission: an Eurocord, PDWP-EBMT analysis. Rubinstein P, Carrier C, Scaradavou A, et al. Gragert L, Eapen M, Williams E, et al. This approach to transplantation relies on GVL because the intensity of the preparative regimen is not sufficient for cure in most cases.
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Improved survival in matched unrelated donor transplant for childhood ALL since the introduction of high-resolution matching at HLA class I and II. González-Vicent M, Molina B, Andión M, et al. Patel B, Pearson H, Zacharoulis S: Mobilisation of haematopoietic stem cells in paediatric patients, prior to autologous transplantation following administration of plerixafor and G-CSF. Matthay KK, Villablanca JG, Seeger RC, et al.
Chimerism-based pre-emptive immunotherapy with fast withdrawal of immunosuppression and donor lymphocyte infusions after allogeneic stem cell transplantation for pediatric hematologic malignancies. Reducing the risk for transplantation-related mortality after allogeneic hematopoietic cell transplantation: how much progress has been made? Woods WG, Neudorf S, Gold S, et al. KIR-ligand incompatibility in the graft-versus-host direction improves outcomes after umbilical cord blood transplantation for acute leukemia. Long-term follow-up of patients who achieved complete remission after donor leukocyte infusions.
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Pediatric Blood and Marrow Transplant Consortium trial. Suppress the immune system or eliminate the recipient T cells to minimize risks of rejection. Impact of HLA class I and class II high-resolution matching on outcomes of unrelated donor bone marrow transplantation: HLA-C mismatching is associated with a strong adverse effect on transplantation outcome. Boeckh M, Nichols WG: The impact of cytomegalovirus serostatus of donor and recipient before hematopoietic stem cell transplantation in the era of antiviral prophylaxis and preemptive therapy. Treatment of high-risk neuroblastoma with intensive chemotherapy, radiotherapy, autologous bone marrow transplantation, and 13-cis-retinoic acid.
Michel G, Galambrun C, Sirvent A, et al. Nonpermissive HLA-DPB1 disparity is a significant independent risk factor for mortality after unrelated hematopoietic stem cell transplantation. Comparison of intensive chemotherapy, allogeneic, or autologous stem-cell transplantation as postremission treatment for children with very high risk acute lymphoblastic leukemia: PETHEMA ALL-93 Trial.
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Gaynon PS, Harris RE, Altman AJ, et al. Vigorito AC, Campregher PV, Storer BE, et al. Howard CA, Fernandez-Vina MA, Appelbaum FR, et al. Chimerism-based pre-emptive immunotherapy with fast withdrawal of immunosuppression and donor lymphocyte infusions after allogeneic stem cell transplantation for pediatric hematologic malignancies. Miller JS, Soignier Y, Panoskaltsis-Mortari A, et al.
Treatment of high-risk acute leukemia with T-cell-depleted stem cells from related donors with one fully mismatched HLA haplotype. Outcome of children with acute leukemia given HLA-haploidentical HSCT after αβ T-cell and B-cell depletion. Horn B, Petrovic A, Wahlstrom J, et al. Whether haploidentical approaches are superior to cord blood or other stem cell sources for a given patient group has not been determined because comparative studies have yet to be performed. Rubnitz JE, Inaba H, Ribeiro RC, et al. ABO mismatch is associated with increased nonrelapse mortality after allogeneic hematopoietic cell transplantation.
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Leung W, Campana D, Yang J, et al. Cunha R, Loiseau P, Ruggeri A, et al. Wagner JE Jr, Eapen M, Carter S, et al.
Eapen M, Rubinstein P, Zhang MJ, et al. Hematopoietic cell transplantation in older patients with hematologic malignancies: replacing high-dose cytotoxic therapy with graft-versus-tumor effects. This approach relies on the persistence of donor T-cell engraftment after transplant to prevent rejection of donor lymphocytes infused to induce the GVL.
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Handgretinger R, Chen X, Pfeiffer M, et al. Leung W: Use of NK cell activity in cure by transplant. Pediatric Blood and Marrow Transplant Consortium trial. Eapen M, Horowitz MM, Klein JP, et al. Persistent MRD before and after allogeneic BMT predicts relapse in children with acute lymphoblastic leukaemia. Identification of a permissible HLA mismatch in hematopoietic stem cell transplantation.
Effectiveness of donor natural killer cell alloreactivity in mismatched hematopoietic transplants. GVL One can deliver GVL therapeutically through infusion of cells after transplant that either specifically or nonspecifically target tumor. GVHD and inferior survival among the children who received PBSCs. Milano F, Gooley T, Wood B, et al. The use of reduced-intensity conditioning and nonmyeloablative regimens is well established in older adults who cannot tolerate more-intense myeloablative approaches, but these approaches have been studied in only a handful of younger patients with malignancies. Higher mortality after allogeneic peripheral-blood transplantation compared with bone marrow in children and adolescents: the Histocompatibility and Alternate Stem Cell Source Working Committee of the International Bone Marrow Transplant Registry.
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Significant improvement in survival after allogeneic hematopoietic cell transplantation during a period of significantly increased use, older recipient age, and use of unrelated donors. Cytotoxic T lymphocyte therapy with donor T cells prevents and treats adenovirus and Epstein-Barr virus infections after haploidentical and matched unrelated stem cell transplantation. Kanda J, Atsuta Y, Wake A, et al. Baron F, Baker JE, Storb R, et al. Rettinger E, Willasch AM, Kreyenberg H, et al. Boyiadzis M, Arora M, Klein JP, et al.
Defining the intensity of conditioning regimens: working definitions. Crocchiolo R, Zino E, Vago L, et al. Feasibility and Outcome of Haploidentical Hematopoietic Stem Cell Transplantation with Post-Transplant High-Dose Cyclophosphamide for Children and Adolescents with Hematologic Malignancies: An AIEOP-GITMO Retrospective Multicenter Study. Donor-specific anti-HLA Abs and graft failure in matched unrelated donor hematopoietic stem cell transplantation. Chimeric antigen receptor-modified T cells for acute lymphoid leukemia.
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Reduced-intensity conditioning: Regimens that are of intermediate intensity and do not meet the definitions of nonmyeloablative or myeloablative regimens. HLA match likelihoods for hematopoietic stem-cell grafts in the U. Reduced-intensity stem cell transplantation in children and adolescents: the Mexican experience. Reduced-intensity allogeneic transplantation in pediatric patients ineligible for myeloablative therapy: results of the Pediatric Blood and Marrow Transplant Consortium Study ONC0313.
Flomenberg N, Baxter-Lowe LA, Confer D, et al. Petersdorf EW, Kollman C, Hurley CK, et al. Kalos M, Levine BL, Porter DL, et al. Bupivacaine Versus a Mixture of 0.
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PBSC: A Children’s Oncology Group study. Effect of HLA class II gene disparity on clinical outcome in unrelated donor hematopoietic cell transplantation for chronic myeloid leukemia: the US National Marrow Donor Program Experience. Haploidentical hematopoietic stem cell transplantation without in vitro T-cell depletion for the treatment of hematological malignancies.
Nonmyeloablative: Regimens that cause minimal cytopenias and do not require stem cell support. Bachanova V, Burke MJ, Yohe S, et al. Pulsipher MA, Peters C, Pui CH: High-risk pediatric acute lymphoblastic leukemia: to transplant or not to transplant? 5 associate with adverse outcomes in hematopoietic stem cell transplantation. Quantification of minimal residual disease levels by flow cytometry at time of transplant predicts outcome after myeloablative allogeneic transplantation in ALL. Cooley S, Trachtenberg E, Bergemann TL, et al.